Postgraduate School
Department of Pharmaceutics and Industrial Pharmacy
Master of Science Pharmaceutics and Industrial Pharmacy
M.Sc. Pharmaceutics and Industrial Pharmacy
| Name | Status and qualification | Research interests |
| Adeola T. Kola-Mustapha | Senior Lecturer & Ag. Head of Dept. B.Sc., B.Pharm. (Lagos); PGDE (Ilorin); M.Sc. (Lagos); Ph.D. (DMU, Leicester) | Drug Delivery, Nanotechnology, Natural Product Formulations |
| A. S. Adebayo | Professor B.Pharm., M.Sc. (OAU, Ile-Ife); M.Sc. (Chicago); Ph.D. (Ibadan) | Biopharmaceutics, Pharmacokinetics |
| I. O. Aremu | Reader B.Pharm. (OAU, Ile-Ife); M.Sc. (Ibadan); Ph.D. (OOU, Sagamu) | Semi-solid Formulation |
| A. O. Shittu | Senior Lecturer B.Pharm., M.Sc., Ph.D. (ABU, Zaria) | Dosage Design and Formulation |
| *Moji T. Bakare-Odunola | Professor B.Sc. (Maiduguri); M.Sc., Ph.D. (ABU, Zaria) | Pharmaceutical Analysis |
| *N. S. Njinga | Senior Lecturer B.Sc. (Buea); M.Sc., Ph.D. (ABU, Zaria) | Natural Products Chemistry |
*Lecturer from other departments
B. Introduction
This is a Postgraduate course in Pharmaceutics and Pharmaceutical Technology designed to provide a critical appreciation of the basic principles of Pharmaceutics in relevant areas of Pharmacy practice. It is anticipated that at end of the programme, the student will attain a high level of expertise in the chosen area of specialization for an enhanced and effective application of acquired knowledge.
C. Philosophy
The philosophy of the programme is to expose students to detailed knowledge and strong research skills to enable them function in areas such as in the academia, pharmaceutical industries and research institutions.
D. Aims and Objectives
The aim of the programme is to develop highly skilled, specialized and proficient scholars in the field of pharmaceutics.
Objectives:
E. Admission Requirements
Candidates are required to possess the following:
F. Duration of Programme
The Full-time programme shall run for a maximum of 18 calendar months and a maximum of 24 calendar months with an extension of 12 months.
G. Detailed Course Description
PCT 801 Advanced Tabletting Technology 3 Credits
Mixing, mechanism and methods; Drying, mechanism and methods. Advanced studies on the selection and control of raw materials, granulation and compaction. Instrumentation of tablet machines, tablet vetting and standardization. 30h (T); 45h (P); C
PCT 802 Advanced Biopharmaceutics and Stability Studies 3 Credits
Drug availability and factors affecting passage through bio membranes: models, symbols, equations used in pharmacokinetics. Compartments: bio and non- bioequivalence. Effect of dosage forms on availability; Relationship between dosage forms, dosage regimens and pharmacokinetics and availability in special conditions such as: paediatric, renal, and liver impairment, pregnancy and disease state. Advanced studies of dosage form design and evaluation. Kinetics of drug degradation, stability of dosage forms – physical, chemical and mechanical degradations; methods of stabilization and accelerated stability studies.30h (T); 45h (P); C
PCT 803 Theory and Formulation of Dosage Forms (Disperse Systems and Controlled Release Dosage Forms) 3 Credits
Modifications of activity of medicament by physical and chemical methods. Control of drug release, evaluation of formulated products, ranking of drug and several formulations of one drug, dosage of drugs for infants, children and adults. Measurement and interpretation of rates of dissolution, estimating bioavailability and in vitro and in vivo correlations. Disperse systems: Advanced studies on surface activity, adsorption at interfaces: solubilization, dispersions of solids in liquid media, emulsion, rheology, flow properties of non-Newtonian materials, suspending and rheological techniques. Controlled Release Dosage Forms: Types, materials, formulations and kinetics of controlled release dosage forms. Evaluation of these products. Advantages and disadvantages of controlled release dosage forms over other conventional dosage forms. 30h (T); 45h (P); C
PCT 804 Advances in Drug Delivery Systems 2 Credits
Optimization of drug release. Application of polymers in drug delivery. Recent advances in controlled drug delivery, site-specific delivery. Application of nanotechnology in drug delivery. 30h (T); C
PCT 805 Industrial Processing, Drug Production and Packaging 3 Credits
Plant and equipment design for pharmaceutical drug manufacture. Equipment handling and maintenance. Good manufacturing practice. Production planning, drug production and in-process controls. Equipment installation, maintenance and processing for purified water production in pharmaceutical industries. Equipment installation, handling and maintenance of air handing system in pharmaceutical industries. Advances in packaging science and counterfeit devices. Evaluation and properties of packaging material design and tolerance of containers. Container: product interactions, closure, biological deterioration of packaging materials, corrosion, packaging of sterile pharmaceuticals, aerosols and packaging materials. Advances in processing of local pharmaceutical raw materials including starch, gum and celluloses. 30h (T); 45h (P); C
PCT 806 Seminar 2 Credits
The student is required to make a critical survey of literature of approved topic in the area of specialization and to give at least two (2) seminars on investigations carried out by the student. 90h (P); C
PCT 807 Dissertation 6 Credits
This is required of all students based on an investigation of a suitable area chosen after due consultation and approval of both the supervisor(s), Head of Department and by relevant committees. The title of the report would be as recommended by the Departmental Postgraduate Committee and subsequently approved by the Board of the Postgraduate School. 270h (P); C
PCT 808 Research Methodology and Biostatistics 2 Credits
This will involve a review of basic statistics from measures of central tendency to pair samples hypothesis: parametric and non-parametric analysis, multi- sample hypothesis and multiple comparisons, two factor analysis of variance, data transformations, multi-way factorial analysis of variance ; linear regression and comparing linear regression equations; simple linear correlation and multiple regressions ; binomial distribution, testing for randomness ; and analysing data using statistical computer packages.30h (T); C
PCT 809 Product Development 3 Credits
Approach to product development. Pre-formulation studies on the properties of drugs and pharmaceutical excipients including physical properties: particles size, solubility, partitioning effect, polymorphism, salt formation, cohesiveness and compressibility, interfacial tension and rheology and chemical properties: hydrolytic degradation, oxidative degradation, racemization, photolytic degradation, drug-excipient and drug- drug interactions. Advanced studies on the properties of some selected materials: physical and chemical evaluation of properties of selected raw materials. Formulation ingredients: surfactants, hydrocolloids, stabilizers, manufacturing additives etc. Modification of activity of medicaments by physical and chemical methods. Evaluation of drugs. Design and formulation of drugs from natural sources. Economics of drug development. Optimization techniques in product development. Modifications of activity of medicament by physical and chemical methods. Evaluation of drugs. 30h (T); 45h (P); C
PCT 810 Advanced Production of Biopharmaceuticals 3 Credits
Recombinant DNA Technology, Production of biopharmaceuticals, including monoclonal antibodies, recombinant antibodies and antibody fragments. Human genome project, Stem cell technology, Gene Therapy-uses, delivery systems, ethical and regulatory issues. 30h (T); 45h (P); E
PCT 811 Sterile Preparations 3 Credits
Injections, non-injectable fluids. Quality of water, pyrogens and apyrogene requirements. Ophthalmic preparations. Good manufacturing practice (GMP). Quality Assurance. Quality Control, In-Process control.General aspects for the manufacturing of pharmaceutical products, contamination control.
Design of clean area: surfaces, pipes and ducts; drains and sinks; provision of clear air samples, clothing, changing facilities and disinfectants. Frequency of cleaning and disinfection of equipment and operation. Sterile-medicinal products – additional requirement; Aseptic areas: the processing environment, equipment, personnel; Biological tests; Test for pyrogens.30h (T); 45h (P); E
PCT 812 Advanced Pharmaceutical Analysis 3 Credits
Analytical Spectroscopy. Analytical Separation. Theory and Practice of Advanced Analytical Techniques with emphasis on non-instrumental aspects. The handling of calculations and application of analytical methodology to real systems will be emphasized. 30h (T); 45h (P); E
PCT 813 Herbal Formulation, Standardization and Packaging 3 Credits
Plant collection, identification, processing and design of dosage form. Standardization and stability of the herbal dosage form. Design of packaging. 30h (T); 45h (P); E
H. Graduation Requirements
The M.Sc. Programme is of two semesters of continuous residency. Candidates are required to register for a minimum of 24 credit units and a maximum of 30 credit units. In addition to passing all core courses, the candidate must register and pass two elective courses. A minimum of 36 credits are required for graduation.The candidate must submit a thesis adjudged to show originality and of significant contribution to knowledge. This should be defended before a Postgraduate School approved External Examiner.
I. Summary
(2), PCT 807 (6), PCT 808 (2), PCT 809 (3) and PCT 813 (3)
30 Credits
Elective courses: PCT 810 (3), PCT 811 (3) and PCT 812 (3) 9 Credits
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